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Coronavirus Special Report — J.C. on a bike — Harvard to the Bighouse

This is a J.C. on a bike Special Report on Coronavirus 2020. SKIP INTRO 2:20

This video and the preceding special reports were inspired by the reporting done here:

Harvard to the Bighouse (@Harvard2H via twitter) https://harvardtothebighouse.com/2020/01/31/logistical-and-technical-analysis-of-the-origins-of-the-wuhan-coronavirus-2019-ncov/

You can jump to the end synopsis at: 27:40

So far most of the circumstantial evidence is not helping to make these theories of highly nefarious activities fade away.

Long story short: It seems likely that the virus 2019-nCoV is a highly virulent virus that was accidentally released from a laboratory in Wuhan, China. It’s unfortunately hard to get reliable numbers simply because they seem to change all the time. One this is certain: So far, it doesn’t seem to be going away like 2003 SARS-CoV did. Therefore, it is warranted to stay aware and alert as the story evolves.

The worst-case scenario is by all reasonable estimations still pretty serious, so let’s hope for better for China and the rest of the world.

I will post any non-video updates in the description section below. Thanks for your time and attention.

Be well, and love your neighbors. J.C.

Again, the primary impetus for this ride series were the following blog, “Harvard to the Bighouse”. The primarily literature listed comprise the additional background reading done for this ride. To be clear, the leg work for this ride was supremely enhanced by the succinct and thorough reporting done the author listed here:

Harvard to the Bighouse (@Harvard2H via twitter) https://harvardtothebighouse.com/2020/01/31/logistical-and-technical-analysis-of-the-origins-of-the-wuhan-coronavirus-2019-ncov/
You can read all the science yourself, although it is cutting edge biology that won’t be fun reading for the non-biologist.

Here’s a quick and dirty annotated bibliography that I think shows we COULD have made SARS-CoV2.

It doesn’t prove we did. But it definitely shows we could. I am not saying we or anyone else would. I am not saying I know who did.

I am specifically saying that to say, “We couldn’t have made this virus” is absolutely false as best as I can tell.

I am specifically saying that we have already collected, cultured, and even made similar viruses (see below).

PNAS paper 2002 showing techniques to use cDNA to generate RNA viruses:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC25860/
Commentary on above:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC33981/

A few papers showing how fun it is to collect bat viruses in the wild:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687304/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466186/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389864/ (This one uses the ACE2 receptor?!)

A nice article about the Gain-of-Function Debate, viruses as weapons:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542197/

A few papers to start with regarding the making of our own chimeric bat coronaviruses:

https://www.nature.com/articles/nm.3985/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006927/

The paper with a culture prep to study viruses and lung epithelium interactions:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744394/

A few papers regarding the crystallography of coronaviruses:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338876/

A couple coronavirus reviews:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369385/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465284/

***** J.C. is an academic [neuro]biologist turned bike-seat science journalist who moved to Pittsburgh in 2016.

After nearly 20K miles on the streets of the City of Champions, J.C. has come to see Pittsburgh as home.

Thanks for watching!

Music by Joakim Karud https://youtube.com/joakimkarud/

Written by J.C. on a bike

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20 Comments

  1. I could have done without the snot rockets toward the end of the ride, but overall, as someone who has been following Dan's blog, I thought this was a very good conversational account of what is going on. Kudos for that and for finally getting some real cardio in around the 15 minute when you made it to the bridge and were able to reach and maintain a speed of 15 to 20 mph for most of the remainder of your ride.

  2. It seems as though we're following the same bread crumbs. People need to be aware of dual-use gain of function research. It's refreshing to see someone shedding light on this dual-edged sword. You should do a bike ride on Bill Gates and how he is personally invested into the coronavirus. He just recently stepped down from Microsoft as I'm sure you're aware. There's so much investment at risk right now.

    People please, I implore anyone who's reading this to look up DUAL-USE GAIN OF FUNCTION RESEARCH". Look up the history of it right up to present day. Research H1N1 and its origins. Research why there was a moratorium placed on gain of function research. What you will find will actually terrify you. The patents are a click away, and you'd be surprised who owns them.

  3. Awesome research, opening the eyes to the blind, in my case, this is my grain of sand: https://www.researchgate.net/post/Third_Sequence_COVID-19_AATGGTACTAAGAGG_HIV-1_isolate_1966324H9_from_Netherlands_envelope_glycoprotein_env_gene_sequence_ID_GU4555031, the most visited of eight; my past one costed me the job and, thus far as I know, absolutely nobody liked it: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272245, here in its original: https://www.researchgate.net/publication/51622946_Escaping_the_Cut_by_Restriction_Enzymes_Through_Single-Strand_Self-Annealing_of_Host-Edited_12-bp_and_Longer_Synthetic_Palindromes, keep up the good reasoning, it is very needed to end the madness of the ones seeking to take advantage of the current pandemic; as we say in Mexico talking about the evil ones in this context: "In troubled waters, the fishers win"!!! (and we are the fishes that need to keep on escaping as soon as possible!!!).

  4. your entire report / thesis is based on info. disseminated by the "Company". How can you come to any conclusion based on manufactured statistics. Have you been able to personally verify any of the official reports or data. How, for example, do you explain , a country such as Bangladesh with 170 million people reporting less than 200 deaths over 3 months.
    A more valuable analysis for me, would have been, to dissect the official actions based on manufactured perceptions explaining, what looks more and more like, a "global drill gone live"

    On may 5 – the extent of this event, as you imagined it, has not materialized, only the predictable hysteria in a terrified population has.

    You were feeding the beast.

  5. your entire report / thesis is based on info. disseminated by the "Company". How can you come to any conclusion based on manufactured statistics. Have you been able to personally verify any of the official reports or data. How, for example, do you explain , a country such as Bangladesh with 170 million people reporting less than 200 deaths over 3 months.

    A more valuable analysis for me, would have been, to dissect the official actions based on manufactured perceptions explaining, what looks more and more like, a "global drill gone live"

    On may 5 – the extent of this event, as you imagined it, has not materialized, only the predictable hysteria in a terrified population has.

    You were feeding the beast

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